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In addition, administration of a single oral 50 mg dose of amitriptyline to 15 normal volunteers who received valproate orally 500 mg twice daily resulted in a 21 decrease in plasma clearance of amitriptyline and a 34 decrease in the net clearance of nortriptyline.

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alleles associated with cyp450 genes, namely cyp2d6 and cyp2c19, are known to influence elimination of amitriptyline and its metabolites.

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