No apparent increase in the incidence of malignancies and lymphoproliferative disorders was reported in the clinical trials of arava, but larger and longer-term studies would be needed to determine whether there is an increased risk of malignancy or lymphoproliferative disorders with arava.
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without use of an accelerated drug elimination procedure, it may take up to 2 years to reach undetectable plasma teriflunomide concentrations after stopping arava see clinical pharmacology .
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