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A dedicated drug interaction study was conducted in 60 healthy volunteers to evaluate the effects of omeprazole 80 mg administered once daily on the pharmacokinetics pk of dipyridamole and the pharmacodynamics pd of acetylsalicylic acid when co-administered with aggrenox twice daily.

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in studies in which dipyridamole was administered in the feed to mice up to 111 weeks in males and females and rats up to 128 weeks in males and up to 142 weeks in females , there was no evidence of drug-related carcinogenesis.

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the committee recognised that the differences in the total costs and qalys for the different treatment strategies each including clopidogrel, modified-release dipyridamole plus aspirin and aspirin were small.

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