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In addition to the adverse reactions noted above, the following adverse reactions have been reported in clinical trials with the sustained-release formulation of bupropion in depressed subjects and in nondepressed smokers, as well as in clinical trials with the immediate-release formulation of bupropion.

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in a clinical trial of 15 male subjects ages 19 to 35 years who were extensive metabolizers of cyp2d6, bupropion 300 mg per day followed by a single dose of 50 mg desipramine increased the cmax, auc, and t of desipramine by an average of approximately 2-, 5-, and 2-fold, respectively.

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a wellbutrin bupropion is classified as a dopamine reuptake inhibitor antidepressant and as a smoking cessation aid.

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bupropion, mirtazapine, tianeptine, agomelatine and moclobemide – this reference treatment-emergent sexual dysfunction.

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glaxosmithkline then developed a sustained-release sr version of wellbutrin which releases bupropion at a slower rate.

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a further analysis of data from the slone epidemiology center birth defects study found no statistically significant increase of left outflow tract heart defects with maternal bupropion use.

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