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Isavuconazole, the active moiety of isavuconazonium, is a sensitive substrate of hepatic isoenzyme cyp3a4; indinavir is a strong inhibitor of this enzyme.
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Trimethoprim minor concomitant administration of indinavir and trimethoprim should be done with caution.
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coadministration is not recommended because indinavir serum levels may be reduced, decreasing the clinical effect and possibly leading to resistance to indinavir or the class of protease inhibitors.