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Methotrexate can cause an abnormal functioning of the liver.

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methotrexate can cause serious or life-threatening side effects on your liver, lungs, or kidneys.

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some patients will have abnormalities in methotrexate elimination, or abnormalities in renal function following methotrexate administration, which are significant but less severe than the abnormalities described in the table below.

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significant drug interactions include increased risk of nephrotoxicity when used with other nephrotoxic agents such as cyclosporine, as well as the potential to increase serum concentrations of methotrexate, with which acyclovir competes for renal excretion.

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should certain beverages, foods and other products be avoided when i take methotrexate.

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biologics are often prescribed together with other medications, such as methotrexate, pain medications, or corticosteroids, and do not seem to interact with most drugs.

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