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the presence of food in the gi tract or delayed gastric emptying increases the extent of absorption of nitrofurantoin by increasing the dissolution rate of the drug; this effect is most apparent when nitrofurantoin is administered as macrocrystals.

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intermedius isolated from urinary tract infections in dogs in the us were highly susceptible to ampicillin, chloramphenicol, trimethoprim sulfamethoxazole, nitrofurantoin, cephalexin, kanamycin and gentamicin.

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maximum urinary excretion usually occurs 2-4 hours after administration of nitrofurantoin.

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antagonism has been demonstrated in vitro between nitrofurantoin and quinolone antimicrobials.


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